Pramiracetam: What is Pramiracetam?
Pramiracetam was first patented in Belgium in 1978 and patented in the United States in 1979. Many researches believe that Pramiracetam’s potency is in the range of 10 to 15 times stronger than that of Piracetam. Pramiracetam has also been shown to be the most lipophilic, allowing it to be absorbed much more rapidly through the lipid bilayers than the other
Racetams. There has been many studies that have explored the potentiality of Pramiracetam being used as a treatment for concussions, Alzheimer’s, as well as senile dementia. Clinical studies have shown several specific therapeutic activities affected by alterations of the cognitive functions. Long term memory improvement has been seen as well as learning, attention span, concentration, alertness, and an increase in the rate of high-affinity choline uptake in the hippocampus.
Pramiracetam is a lipid-soluble nootropic of the Racetam chemical family, and has a relatively similar chemical structure compared to its cousin Aniracetam. However, Pramiracetam is considerably much stronger than Aniracetam. Pramiracetam has the capabilities of increasing the long term memory of individuals, allowing information and knowledge obtained during the effective period of Pramiracetam to be recalled more easily. Considering that the high-affinity choline uptake (HACU) is increased implies an increase in the synthesis and release of Acetylcholine. This shows that Pramiracetam increases both the Hippocampal Acetylcholine activity and the learning and memory encoding process.
A study found that Pramiracetam was able to help improve memory and delayed recall in young men with memory and cognitive problems caused by head injury or anoxia. The study was against a placebo, and showed that not only was Pramiracetam safe but also effective during 
the 18 month period as well as a month after the Pramiracetam’s usage was halted. Brain Inj. 1991 Oct-Dec;5(4):375-80. Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia.
Pramiracetam not only helps improve the cognitive functionality of a mind but has also been shown to exhibit an inhibitory action against platelet hyperactivity under the conditions of chronic hyperglcemia. Eksp Klin Farmakol. 2012;75(4):38-41. [Platelet hyperreactivity and antiaggregatory properties of nootropic drugs under conditions of alloxan-induced diabetes in rats].
Pramiracetam Dosage
The recommended dosage of Pramiracetam is usually 600-900 mg per day, taken as 300 mg individual dosages, one in the morning and one in the afternoon. Pramiracetam is sold in capsule, tablet and powder form.
Does Pramiracetam Work?
Pramiracetam has several potential mechanisms of action from the increase of the High-Affinity Choline Uptake, to the possibility of acting on a peripheral site which relies on the Adrenal glands, as well as the restoration of membrane fluidity allowing more efficient and effective cell signalling.
There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Pramiracetam would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices. Pramiracetam is similar in nature to piracetam though more potent. It is said to enhance memory and cognitive function.
Neuro-Vortex® Pramiracetam (30ct)