Idebenone was first developed and made in Japan by the Takeda Pharmaceutical Company to aid in treating cognitive degenerative diseases and defects such as Alzheimer’s. Eventually the Swiss company Santhera Pharmaceuticals began testing it as a treatment for neuromuscular diseases. This nootropic shows many similarities that has caused it to be compared to CoQ10 by commercial businesses.
Idebenone has been shown to have anti-aging and antioxidant properties. This nootropic may promote the brain health longevity and stimulate nerve growth in most individuals. Over the years, this substance has been labeled to be a cognitive enhancing nootropic and/or an antioxidant.
Idebenone is a soluble in alcohol and menthanol however is insoluble in water. Idebenone has been shown to have some neuro-protectant and regenerative qualities such as the prevention of platelet aggregation and the rejuvenation of cholinergic and monaminergic changes to murine models. This nootropic has also been shown in other studies to display a capability of increasing nerve growth factor production in astrocytes.
A study found Idebenone prescriptions in Argentina had grown significanly in a year. Idebenone is being used as a pharmaceutical to aid in the treatment of cognitive impairment and dementia treatment in young to middle aged patients in Argentina. Brain Inj. Medicina (B Aires). 2013;73(3):213-23. [Drugs used for cognitive impairment. Analysis of 1.5 million prescriptions in Argentina]
Idebenone not only helps improve the cognitive functionality but when used with either Melatonin or Arginine it has been found to help preserve liver functionality. Showing that Idebenone has a wide array of beneficial qualities to it beyond being a nootropic. World J Gastroenterol. 2012 Nov 28;18(44):6379-86. doi: 10.3748/wjg.v18.i44.6379.
Dietary supplementation of some antioxidants against hypoxia.
Idebenone Dosage
The recommended dosage of Idebenone is usually 125-375 mg per day, taken as 125 mg individual dosages, one in the morning and one in the afternoon. Idebenone is sold in capsule, tablet and powder form.
Does Idebenone Work?
Idebenone has several potential benefits from improving visual conditions, regenerating some of the neural pathways such as the cholinergic, and also has positive benefits in overall health. This makes Idebenone a health conscious addition to any nootropic stack. In other words, this nootropic may be added or stacked with other nootropics to benefit overall mind health and cognition.
There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Idebenone would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.
Neuro Mend® – Idebenone